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pd_meltingpoint:284-286oC
Appearance:white powder
Purity:99%
Description |
Astragaloside A (Astragaloside IV) is the primary pure saponin isolated from Astragalus membranaceus, which has been widely used for the treatment of cardiovascular diseases. |
Uses |
Astragalosides are bioactive saponins isolated from dried roots of plants of the genus Astragalus, which is used in traditional Chinese medicine. Astragaloside A, also known as astragaloside IV, is known to have diverse protective effects for the cardiovascular, immune, digestive, and nervous systems. More specifically, it protects cardiomyocytes from apoptosis resulting from ischemia/reperfusion and inhibits inflammation signaled through TNF-α. Furthermore, astragaloside A stimulates angiogenesis, promotes the differentiation of neural stem cells, and increases neuroregeneration. |
Health effects |
As the main active ingredient of the Chinese medicine Astragalus membranaceus, Astragaloside A has a good regulatory effect on the heart. It can protect against ischemic and hypoxic cardiomyocytes, protect the heart structure, and enhance heart function. |
Pharmaceutical Applications |
Astrageloside A has multiple pharmacologic effects, including anti-inflammatory, antifibrotic, antioxidative stress, anti-asthma, antidiabetes, immunoregulation, and cardioprotective effect via numerous signaling pathways. According to the existing studies and clinical practices, Astragaloside A possesses potential for broad application in many diseases. |
InChI:InChI=1/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25-,26-,27?,28-,29+,30?,31-,32-,33-,34+,37+,38-,39+,40-,41+/m0/s1
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3-O-(2,3,4-tri-O-benzoyl-β-D-xylopyranosyl)-6-O-(2,3,4,6-tetra-O-benzoyl-β-D-glucopyranosyl)-16,25-di-O-acetylcycloastragenol
astragaloside IV
Conditions | Yield |
---|---|
With sodium methylate; In methanol; at 20 ℃; for 15h;
|
76% |
astragaloside VI
astragaloside IV
Conditions | Yield |
---|---|
hesperidinase; In water; acetone; at 35 ℃; for 36h;
|
35 mg |
cyclosiversioside H
isoastragalosides II
isoastragaloside I
(3β,6α,16β,20R,24S)-20,24-epoxy-16-hydroxy-3-(β-D-xylopyranosyloxy)-9,19-cyclolanostane-6,25-diyl bis[β-D-glucopyranoside]
cycloastragenol
cyclosieversigenin 6-O-β-D-glucopyranoside
astragenol
cyclosieversigenin 3-O-β-D-xylopyranoside
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